Caspase-3, liver function test and trace elements in Iraqi women with breast cancer

Abstract

Introduction: Cancer is a class of diseases characterized by out-of-control cell growth. Breast cancer is most common disease among women. Aim: The aim of this study to investigate Caspase-3, liver enzyme and trace elements (Iron, magnesium and phosphorus) in women whose suffered from breast cancer. Materials and Methods: Three groups of Iraqi women were chosen named group I (50 healthy women), group II (32 patients new diagnosed with breast cancer and do not take chemotherapy) and group III (43 patients have taken chemotherapy). From the results, On the other hand, the study have been measurement of some biochemical variables, including caspase-3 enzyme, liver enzymes (ALT, AST, ALP) and measuring important trace elements that may have an effect on breast cancer, which included (magnesium, iron and phosphorous). Results: The results showed a significant decrease (P<0.05) between group I and group II in both magnesium and ALT. There was a significant decrease between the group I and the group III in magnesium and a significant increase (P<0.05) between the group I and the group II in iron. In addition, AST and iron levels increased significantly between groups I and III.