Abstract
A better understanding of immune underpinnings of food allergy and interventional desensitization is imperative to design effective oral immunotherapy (OIT) protocols for varied food allergens. To this end, we probed immune changes in participants of our open label cashew and shrimp OIT trial- MOTIF (NCT03504774). In this study, the participants were treated with increasing dose of cognate allergen for 52 weeks followed by 6 weeks of avoidance. Participants successfully desensitized post-OIT were classified into two groups, namely SU4043 (n=23) and SU2043 (n=5) based on the cumulative tolerated allergen protein dose of 4043 mg and 2043 mg respectively during the post-avoidance (i.e., week 58) oral food challenge.
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