Abstract
BackgroundThis study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer.MethodsWe conducted a case-controlled study including 577 primary gastric cancer and 678 normal control cases. The target gene fragment was amplified using PCR using blood samples collected from patients. Allele analysis and genotyping were performed using snapshot method.ResultsThe findings showed that the control group had consistent genotype frequency distribution and presented Hardy–Weinberg equilibrium. The results showed no significant differences in sex, drinking history and age distributions between subjects with the polymorphism and subjects in the control group. Smoking status was correlated with incidence of gastric cancer (P = 0.006). The rs1801173 locus of TP73 gene contained 3 genotypes including: TT, CT, and CT. Logistic regression analysis showed that distribution of recessive model and dominant model was comparable between the two groups before (P = 0.688; 0.937) or after (P = 0.703; 0.990) adjusting for confounders. The distribution frequency in case group was not significantly different relative to that of the control group (P = 0.763).ConclusionSmoking can independently influence the risk of gastric cancer. TP73 gene rs1801173 polymorphism was not significantly correlated with risk of gastric cancer.
Highlights
This study investigated the role of tumor protein P73 (TP73) gene polymorphism, rs1801173on risk of gastric cancer
The findings indicated that rs1801173 of TP73 gene was present on the first chromosome (Table 1)
The findings showed that rs731173 allele frequency distribution of TP73 gene was not significantly different
Summary
This study investigated the role of TP73 gene polymorphism, rs1801173on risk of gastric cancer. Gastric cancer (GC) is a malignant tumor characterized by high incidence worldwide. It is the third leading cause of cancer-related deaths, despite a recent decline in overall incidence[1]. The progression landscape of gastric cancer is complex and involves numerous factors. Genetic factors such as single nucleotide polymorphisms (SNPs) are implicated in GC development in addition to environmental risk factors including helicobacter pylori (HP) infection and diet. The tumor protein P73 (TP73) belongs to TP53 family This family includes well-defined tumor suppressors, TP53 (p53) and TP63 (p63). These family members have a wide range of functions, including differentiation, tumor suppression, reproduction, aging, genome repair, stem cell biology, changes in epigenetic markers, metabolic
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