Abstract
Introduction: Glioblastoma multiforme (GBM) is a World Health Organization stage IV astrocytoma with an annual incidence in North America of 5 per 100,000 populations. The male: female ratio is 3:2, and the tumor is usually diagnosed in the 5th or 6th decade of life.Purpose: To identify specialized centers where experienced neurosurgeons, working in the most technologically advanced settings, can provide the most extensive resections while preserving normal brain tissue. Method: Search different internet data bases including: using “pubmed,” “science direct,” “highwire” and “scientific Google” database.Conclusion: is the most common and lethal type of primary brain tumor with a very poor prognosis. Current therapies for GBM remain palliative and advances made in decades have resulted in only a slight improvement in treatment outcome.Recommendations: Exploring new therapeutic agents for GBM treatment, therefore, is of prime importance. In the present study, we performed a high-throughput screening for GBM cell growth and invasion, with an attempt to identify novel potential anti-GBM agents.
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