Abstract
Objective: Placental mesenchymal dysplasia (PDM) is a rare disease, the cause is unknown, some are called mesenchymal stem hyperplasia, and some are called pseudo-vesicular block or vascular malformation. The aim is to report the clinical and pathologic characteristics of three cases of placental mesenchymal dysplasia (PMD). Method: Pathologic and clinical data were retrieved from the electronic medical records. The data were reviewed and summarized by the same pathologist. Results: Maternal age was respective 36 years, 31 years and 33 years. Cesarean section was performed at 39 weeks, 37 weeks and 38 weeks, respectively. The newborns were born with birth weight of 1790, 2370 and 3150 grams, respectively, with placenta weight of 590, 579 and 510 grams respectively. Placenta for pathological examination was performed macroscopically thick-walled vessels. Microscopic observation showed that the part of the stem villus was saclikely dilated, the blood vessels were thickened in the villi, the blood vessel wall was thickened, the villus interstitial was loose, and the mucus was changed. Part of the villus edema and degeneration, no trophoblastic hyperplasia, the final villus structure is normal. Conclusion: The size of the lesions in the Placental mesenchymal dysplasia and the location of the lesion is closely related to the birth weight of the newborn. Detailed histology is necessary for diagnosis and differential diagnosis.
Highlights
Placental mesenchymal dysplasia (PMD) is a relatively rare placental lesion, which is often difficult to identify with vesicular blocks due to the lack of awareness of the disease by clinicians
The present study aims to organize and collect the recent two cases of newborn babies in live births, review the clinical and pathological data, and improve the understanding of the disease by clinical and pathologists through previous literature and clinical-pathological analysis
The fetal membrane spontaneously ruptured, because the pregnant woman has a history of cesarean section, scar uterus, accompanied by cesarean section
Summary
Placental mesenchymal dysplasia (PMD) is a relatively rare placental lesion, which is often difficult to identify with vesicular blocks due to the lack of awareness of the disease by clinicians. The present study aims to organize and collect the recent two cases of newborn babies in live births, review the clinical and pathological data, and improve the understanding of the disease by clinical and pathologists through previous literature and clinical-pathological analysis
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