Abstract
Background: HIV-infected patients are prone to nutritional problems and are at risk to inflammation-driven premature endothelial injury. Elevated homocysteine (Hc) levels are associated with an increased risk for cardiovascular events. Deficiency of the vitamins B6, B12 and folic acid may contribute to endothelial as well as neurocognitive and/or neuropathic complications. MethodsM p=0.04 [Chi2 test]). No other associations were detectable. Conclusion: In our study, hyperhomocysteinemia is not related to a distinct vitamin deficiency and is independently associated with a significant risk of having AIDS.The elevation may rather due to inflammatory events than to metabolic deficiencies. If vitamin supplementation ameliorates hyperhomocysteinemia and its potential consequences has to be proven. The significance of vitamin deficiency itself in HIV-infected individuals remains to be determined.
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