CASE REPORT: THREE CASES OF NON-UNION FRACTURE IN DOGS TREATED WITH ADIPOSE-DERIVED ADULT STEM CELLS COMBINED WITH AUTOLOGOUS CANCELLOUS BONE AND SYNTHETIC BONE SUBSTITUTES

Abstract

The first case was a 4-year old, 10[Formula: see text]kgs intact male Shiba Inu presenting fracture of the distal third of its right ulna and radius. The patient was first managed at a Local Veterinary Hospital (LVH) twice with bone plates but non-union was observed, along with bone infection and bone defect on a large area. The fracture site was re-stabilized and given stem cell therapy at Famous Veterinary Hospital (FVH). The area of bone defect reduced significantly with prominent callus formation. The second case was a 9-year old, 3.3[Formula: see text]kgs intact female Toy Poodle with fracture of the distal right radius and ulna. The fracture was first stabilized with bone plates at LVH but non-union was observed. Resorption of bone was visible radiographically around the proximal screw, which led to fracture and implant loosening at that location. Pan-arthrodesis followed after stem cells administration was performed at FVH. Radiography showed sufficient growth of the radius and union of the ulna occurred at 145 days after therapy. The third case was a 3.5-year old, 10[Formula: see text]kgs intact male Mongrel attended at LVH for a humerus fracture. Fracture reduction with bone plates was attempted twice at LVH but both loosened eventually. At FVH, an external skeletal fixator was used to stabilize the fracture, followed by stem cell therapy. There was radiographic evidence that the humerus healed well by the 35th day after therapy and was completely united by Day 113 of post-surgery and therapy.