Abstract
Breast and endometrial cancer are the most common types of female cancers, but the incidence of both of these malignancies in a single patient is a rare event. Multiple primary malignancy has been increasingly reported over the past decade, and double primary cancer is considered as the most common type. In this study, we present a 53-year-old woman with synchronous primary malignancy of breast and endometrium. This patient had a history of breast and endometrial cancer in her family. Mammography and chest CT of the patient revealed a mass in the right breast and left supraclavicular region. However, the patient did not want to initiate treatment. Subsequently, the patient returned with a chief complaint of persistent abnormal vaginal bleeding. Abdominopelvic CT scan of the patient revealed a huge soft tissue mass in the pelvic cavity. She underwent hysterectomy, and pathology revealed endometrioid carcinoma, which had invaded the full thickness of uterine wall. Since this type of malignancy is rare and several risk factors are associated with it, it is worth being considered by clinicians when making decisions about screening or strategy for prevention.
Highlights
Breast cancer (BC) is the most frequently diagnosed malignancy worldwide and is the first cause of cancer death in women[1]
We present a patient with two primary malignant tumours, including BC and endometrial cancer (EC), which can be considered as synchronous Multiple primary malignancy (MPM)
The possibility of synchronous BC and EC in one person is extremely low, as reported in one study the diagnosis of EC within one year after the diagnosis of primary BC is less than 0.05%8
Summary
Breast cancer (BC) is the most frequently diagnosed malignancy worldwide and is the first cause of cancer death in women[1]. We present a patient with two primary malignant tumours, including BC (invasive ductal carcinoma) and EC (endometroid cell type), which can be considered as synchronous MPM. The mass was diagnosed as BC, the patient personally refused to get any treatment She has a positive family history of breast cancer and uterine cancer in her sister. Pelvic wall mass resection and cervix excision revealed the invasion of the tumour, but peritoneal fluid cytology was negative for malignancy. After two days she discharged from hospital with relative improvement. At the final follow-up, the patient was referred to the oncology department in a different hospital to initiate chemotherapy Besides these factors, hormonal status has an important role in endometrial carcinogenesis. The present case had a family history of breast and uterine cancer, so heredity could be counted as one of the strongest risk factors for this patient
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