Abstract
Heparin is the anticoagulant of choice during pregnancy. However, in cases of intolerance or adverse effects, another anti-coagulant agent should be administered. Here, we describe a case of hypersensitivity skin reaction seen in a 37-year-old pregnant patient at 11 weeks of gestation who used low-molecular-weight heparin (LMWH). Fondaparinux was used as an alternative during her pregnancy with a successful outcome.
Highlights
Low-molecular-weight heparin (LMWH), such as enoxaparin, is the preferred anticoagulant for pregnant women due to its effectiveness, safety, and availability
Fondaparinux, which is a synthetic polysaccharide inhibitor of activated factor X (FXa), has been reported to be a successful alternative anticoagulant in pregnant patients who develop heparin intolerance, such as hypersensitivity skin reaction, which is frequently seen in pregnant patients[1]
Case report A 37-year-old Saudi female homemaker (G6P4+1) with a history of hypothyroidism on thyroxin and a history of miscarriage and intrauterine fetal death (IUFD) presented to our thrombosis clinic. She explained to us that this is an important pregnancy for her and that she wished to deliver a healthy baby. Her gynecological history comprised of: preeclampsia during her first pregnancy, resulting in premature labor; fetal distress during her second pregnancy; a third pregnancy resulting in premature labor at 30 weeks; a fourth pregnancy resulting in IUFD at 25 weeks; fetal distress in the 31st week of her fifth pregnancy in 2012; and a sixth pregnancy resulting in IUFD in 2015
Summary
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