Abstract
Background: Hypokalemic periodic paralysis (HypoKPP) is characterized by transient episodes of flaccid muscle weakness. We describe the case of a teenaged boy with HypoKPP and hyperthyroidism due to Hashimoto's thyroiditis with initial manifestation of renal tubular acidosis. This combination is rare and little described previously in men. Case presentation: A 17-year-old boy was admitted after three days of muscular weakness and paresthesia in the lower limbs with an ascending evolution, leading to prostration. Decreased strength was found in the lower limbs without a defined sensory level, reduced patellar and ankle reflexes. Positive antithyroid antibodies were found. He received hydration treatment, IV potassium and levothyroxine, with which there was a clinical improvement. Other examinations led to the diagnosis of type 1 renal tubular acidosis. Conclusion: HypoKPP is a rare disorder characterized by acute episodes of muscle weakness. Type 1 renal tubular acidosis can occur as a consequence of thyroiditis, which is explained by the loss of potassium. This combination is unusually rare, and has not been described before in men. The etiopathogenesis of the disease as well as a dynamic explanation of what happened with the patient are discussed in this report.
Highlights
Hypokalemic periodic paralysis (HypoKPP) is an uncommon neuromuscular disorder characterized by transient episodes of flaccid muscle weakness, and exceptionally, respiratory failure and death[1,2]
We report the case of a teenaged boy with HypoKPP and hypothyroidism due to Hashimoto’s thyroiditis with initial manifestation of Renal tubular acidosis (RTA)
RTA is a rare cause of HypoKPP6,9–12
Summary
2. Stalin Viswanathan , JIPMER, Puducherry, Keywords hypokalemic periodic paralysis; distal renal tubular acidosis (type 1); hypothyroidism; Hashimoto Disease. Author roles: Meregildo-Rodríguez ED: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – Original Draft Preparation, Writing – Review & Editing; Failoc-Rojas VE: Conceptualization, Data Curation, Formal Analysis, Investigation, Methodology, Resources, Supervision, Validation, Writing – Original Draft Preparation, Writing – Review & Editing. The title was edited to include ‘Hashimotos thyroiditis’ instead of just ‘thyroiditis’ This was answered on the website to each reviewer
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