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Abstract
Inflammatory myofibroblastic tumour (IMT), also known as plasma cell granuloma (PCG) or inflammatory pseudotumour (IPT), is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. IMT predominantly affects children and young adults, and the age at presentation ranges from 3 to 89 years. We present a very rare case of recurrent testicular IMT without ALK rearrangement. This case highlights the clinical characteristics and diagnostic factors associated with primary and recurrent foci of this rare tumour, along with key therapeutic approaches.
Highlights
Inflammatory myofibroblastic tumour (IMT), known as plasma cell granuloma (PCG) or inflammatory pseudotumour (IPT), is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils [1, 2]
We report the first case of a patient with recurrent testicular IMT and review the relevant literature to raise awareness of the clinical characteristics and diagnostic factors associated with primary and recurrent foci of this rare tumour, along with key therapeutic approaches
IMT, known as PCG or IPT, is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils [1, 2]
Summary
Inflammatory myofibroblastic tumour (IMT), known as plasma cell granuloma (PCG) or inflammatory pseudotumour (IPT), is a distinctive, rarely metastasizing neoplasm composed of myofibroblastic and fibroblastic spindle cells accompanied by inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils [1, 2]. The postoperative pathological examination revealed abnormal testis parenchymal structure with large numbers of infiltrating lymphocytes and plasma cells, lymphatic follicles, and proliferating fibroblasts and myofibroblasts; scattered R-S cells could be seen in some areas (Figure 3). At the 27th month of follow-up, the patient presented with a mass in the left lower abdominal wall. B-ultrasonography revealed a deep subcutaneous mass in the left lower abdominal wall. The patient returned during the 29th month of follow-up due to the slow and painless growth of the mass in the left lower abdominal wall. B-ultrasonography indicated a hypoechoic solid mass in the proximal area of the left lower abdominal wall, approximately 4.3×3.1×2.5 cm in size. Informed consent was obtained from the patient to perform an extensive tumorectomy of the left lower abdominal wall. The patient was diagnosed with recurrent IMT based on the results of these postoperative examinations. The patient attended follow-up for another 27 months, and no further recurrence occurred
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