CASE REPORT ON RARE DE-DIFFERENTIATED GIST OF STOMACH OCCURRING DENOVO

Abstract

We present a rare case of de-differentiated GIST. GIST being the most common mesenchymal tumor of alimentary canal is commonly reported. However, de-defferentiation of GIST is a rare phenomenon which may occur denovo or with imatinib therapy. A 57 year old female patient presented with generalized weakness and anemia. On evaluation, a submucosal lesion on the body of stomach along the greater curvature was identied on UGI endoscopy. On CECT scan of abdomen, polypoidal intraluminal mass was seen. After sleeve gastrectomy histopathological examination showed dedifferentiated GIST, stomach which was conrmed on IHC. The patient had no prior history of Imatinib therapy/ any chemotherapy. We present this case as de-differentiated GIST occurring denovo without prior imatinib therapy is rare and not much is known about its clinical course and prognosis of such cases.