Abstract
1. 1. A longitudinal and naturalistic study of nine bipolar patients attending a lithium clinic during a six-month period was undertaken. 2. 2. Prolactin plasma levels and psychiatric symptoms were evaluated biweeekly. 3. 3. Wide interindividual and intraindividual fluctuations were observed both in prolactin levels and psychiatric symptoms. 4. 4. The relationship between prolactin and affective episodes was found to be complex. 5. 5. In a few instances, sharp prolactin changes preceded behavioral modifications. 6. 6. Bipolar disorders, even if treated, appeared to be unstable conditions, from both the phenomenological and neuroendocrinological viewpoints.
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