Abstract
Lymphoma of the uterine cervix is very rare. We report a case of diffuse large B cell lymphoma (DLBCL) involving the uterine cervix treated at a newly commissioned semiurban cancer centre in north India in 2015. Data for this study was obtained from the hospital electronic medical records and the patient's case file. We also reviewed published case reports of uterine and cervical lymphoma involving forty-one patients. We treated a case of stage IV DLBCL cervix with six cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) and intrathecal methotrexate followed by consolidation with radiotherapy. The patient showed complete response to chemotherapy. We conclude that, in advanced stage lymphoma involving uterus and cervix, combination of chemotherapy and radiotherapy is effective in short term.
Highlights
Non-Hodgkin’s Lymphoma (NHL) affects extranodal sites in one-third of cases
We report a case of diffuse large B cell lymphoma (DLBCL) involving uterine cervix and provide a review of literature of cervical lymphoma
DLBCL accounted for 80% and 50% of cases in the two groups, respectively, the remainder being constituted by follicular lymphoma, small lymphocytic lymphoma, marginal zone B cell lymphoma, and precursor T cell lymphoblastic lymphoma
Summary
Non-Hodgkin’s Lymphoma (NHL) affects extranodal sites in one-third of cases. The most commonly affected extranodal sites are the gastrointestinal tract and skin. May female reproductive organs be involved, most commonly ovary. NHL of the cervix is extremely rare. Cervix was involved in 1 out of 730 cases of NHL and 1 out of 175 cases of extranodal lymphoma [1]. It is usually a high grade B cell lymphoma [2] with abnormal vaginal bleeding as the most common presenting symptom (60%) [3]. We report a case of DLBCL involving uterine cervix and provide a review of literature of cervical lymphoma
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