Abstract
In this report, we described a 58-year-old man, presenting with multiple plaques and nodules over the nose and forehead resembling sarcoidosis or lepromatous leprosy. The histologic study revealed deposition of the mass of amorphous, eosinophilic-cleaved, colloid materials in the papillary dermis and deep dermis. The periodic acid-Schiff (PAS) stain was positive, whereas the Congo red stain was negative. Based on the clinical and pathologic findings, the patient was diagnosed with nodular colloid degeneration(NCD). To treat the patient, lesions were flattened using a Co2 laser. The patient did not return for follow-up. NCD is a rare disease, with only 12 cases having been previously reported. Here, we present a case of NCD that occurred on the face and discuss the topic of how to discriminate between NCD and other similar entities, emphasizing that nodular colloid degeneration should be considered in the differential diagnosis of asymptomatic facial plaques and nodules.
Highlights
Nodular colloid degeneration (NCD), named paracolloid, is a rare subtype of colloid deposition disorders
We present a case of NCD that occurred on the face and discuss the topic of how to discriminate between NCD and other similar entities such as nodular amyloidosis
The four variants of this disease are as follows: adult colloid milium, juvenile colloid milium, pigmented colloid milium, and nodular colloid degeneration[2]. In both the adult and juvenile forms, numerous yellow-brown, semitranslucent dome-shaped papules are developed in areas of chronic sun exposure; for example, the cheeks, ears, neck, and dorsum of the hands
Summary
Any reports and responses or comments on the article can be found at the end of the article. Author roles: Niknezhad N: Writing – Original Draft Preparation, Writing – Review & Editing; Bidari-Zerehpoosh F: Writing – Original Draft Preparation; Niknejad N: Writing – Original Draft Preparation, Writing – Review & Editing; Mozafari N: Writing – Original Draft Preparation, Writing – Review & Editing. Grant information: The author(s) declared that no grants were involved in supporting this work. How to cite this article: Niknezhad N, Bidari-Zerehpoosh F, Niknejad N and Mozafari N.
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