Abstract
A multifocal biphasic squamoid alveolar renal cell carcinoma in a 68-year-old man is reported. Four different peripheral tumor nodules were identified on gross examination. A fifth central tumor corresponded to a conventional clear cell renal cell carcinoma. Biphasic squamoid alveolar renal cell carcinoma is a rare tumor that has been very recently characterized as a distinct histotype within the spectrum of papillary renal cell carcinoma. Immunostaining with cyclin D1 seems to be specific of this tumor subtype. This is the first reported case with multifocal presentation.
Highlights
The so-called biphasic squamoid alveolar renal cell carcinoma (BSARCC) was described for the first time in 2012 by Petersson et al.[1] and has been very recently revisited and fully characterized by Hes et al.[2]
Histological, immunohistochemical, comparative genomic hybridization and fluorescence in situ hybridization analyses have revealed that BSARCC is a renal neoplasm closely related to papillary renal cell carcinoma (PRCC)[2]
The present paper describes a new BSARCC with multifocal presentation that was associated with a conventional clear cell renal cell carcinoma (CCRCC)
Summary
Any reports and responses or comments on the article can be found at the end of the article. The new version takes into consideration all the reviewers’s comments and clarify a misunderstanding in the text. Figures have been modified, as requested, to highlight the squamoid cell nests and to give a more detailed approach to the immunohistochemical profile of the tumor. The distinct distribution of the cyclin D1 along the tumor has been detailed. Cyclin D1 immunostaining was restricted to the squamoid cells, a point that was not clear in the former version. Some references supporting that cyclin D1 can be detected in other renal neoplasms have been included in the reference list.
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