Abstract
Here we report a critically ill patient who was cured of SARS-CoV-2 infection in Changsha, China. A 66-year-old Chinese woman, with no significant past medical history, developed severe pneumonia-like symptoms and later diagnosed as severe COVID-19 pneumonia. Within 2 months of hospitalization, the patient deteriorated to ARDS including pulmonary edema and SIRS with septic shock. When treatment schemes such as antibiotics plus corticosteroids showed diminished therapeutic value, hUCMSC therapy was compassionately prescribed under the patient's consent of participation. After treatment, there was significant improvement in disease inflammation-related indicators such as IL-4, IL-6, and IL-10. Eventually, it confirmed the therapeutic value that hUCMSCs could dampen the cytokine storm in the critically ill COVID-19 patient and modulated the NK cells. In the continued hUCMSC treatment, gratifying results were achieved in the follow-up of the patient. The data we acquired anticipate a significant therapeutic value of MSC treatment in severe and critically ill patients with COVID-19, while further studies are needed.
Highlights
At the end of 2019, several cases of severe respiratory infections were identified in Wuhan, China, which were triggered by a novel virus that was later assigned the name SARS-CoV-2 or COVID-19
Based on these prepositional studies, our center is currently working on another randomized and more sophisticated study to verify the therapeutic value of Mesenchymal stem cells (MSCs) treatment in severe and critically ill patients with COVID-19 pneumonia, with the expectation to promote its potential long-term efficacy and decrease its toxicity
It is commonly known that COVID-19 patients, severe- and critically ill-type cases, in particular, are frequently accompanied by “cytokine storm.”
Summary
At the end of 2019, several cases of severe respiratory infections were identified in Wuhan, China, which were triggered by a novel virus that was later assigned the name SARS-CoV-2 or COVID-19. In consideration of the current dire situation, we would like to share our experience in critical care of an elderly patient who had no existing medical conditions and later transformed into critically ill COVID-19 case This patient had developed multiple severe virus-induced syndrome and yet successfully recovered after continuous treatments of combined antibiotic therapy and an innovative human umbilical cord mesenchymal stem cell (hUCMSC) intervention. This case highlights our patient’s clinical course, including relevant medical history, diagnostic work-up, medical management, and challenges in respiratory function and immunologic function supplement, as well as pulmonary fibrosis repairing. These findings indicated that the use of hUCMSCs was safe and well-tolerated by the patient
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