Abstract
Histiocytic sarcoma was diagnosed in a 8.5-month-old SPF inbred DBA/2J mouse on routine heaIth monitoring. Grossly, the tumor was characterized by hepatomegaly with mottled greyish spots, splenomegaly and enlargement of the left testis and epididymis. The neoplastic cells marked by infiltrating the liver, left testis and epididymis, lung, the serosa of kidneys and jejunum. The neoplastie cells exhibited moderate pleomorphism and ranged from fusiform to ovoid in shape, with large nuclei. The cytoplasm was pale staining or composed of moderate amount of light eosinophilic foamy vacuoles. Multinucleated giant cells were rarely seen. The morphological features with immunohistochemical characteristics of the present case were in favor of the diagnosis of histiocytic sarcoma.
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