Abstract
Recently, a few case reports and clinical studies have been published that explore the association of Behçet's Disease (BD) and vitiligo, with conflicting results. Genetic and immunological properties of BD and presence of autoantibodies support autoimmunity, but clinical features suggest autoinflammatory diseases. BD is thought to be a cornerstone between autoimmune and autoinflammatory diseases. On the other hand, vitiligo has been accepted as an autoimmune disease with associations of other autoimmune disorders and there is a possible role of autoimmunity in pathogenesis of the disease. Significant advances have been made understanding the pathogenesis and genetics of BD. However, it is worth presenting rare clinical variants for improving the clinical understanding of BD. Herein, we are presenting a case with diagnosis of both Behçet's disease and vitiligo in same patient, which is a rare occurrence. Discussion and demonstrating the association of these two diseases may give rise to understanding similar and different aspects of autoimmunity and autoinflammatory pathogenesis of both diseases.
Highlights
Behçet’s disease (BD) is a systemic disease with an unknown origin characterized by recurrent oral ulcers, mucocutaneus disorders and ocular findings
Clinical characteristics and symptoms are the main factors for diagnosing BD, but a specific diagnostic feature or laboratory method is not yet available
We present a case of BD accompanied by vitiligo
Summary
2. Rasheedunnisa Begum , Maharaja Sayajirao University of Baroda, Vadodara, India. Any reports and responses or comments on the article can be found at the end of the article. Keywords Behçet’s Disease, Vitiligo, Autoimmunity, Autoinflammatory, Depigmentation, Erythema nodosum, Thrombophlebitis, Arthritis. Grant information: The author(s) declared that no grants were involved in supporting this work.
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