Abstract
A recently observed case of deep infiltrating endometriosis with its vaginal invasion diagnosed by vaginal cytology is reported. A 28-year-old Japanese woman complained of a severe dysmenorrhea. Left ovarian endometriotic cyst and deep infiltrating endometriosis were suspected. Two red-spots were also present in the posterior fornix of vagina. Vaginal cytology with cytokeratin (CK) 7-immunocytochemistry suggested the presence of infiltrating endometriosis. She underwent left ovarian cystectomy and resection of thickened uterosacral ligaments with vaginal endometriotic spots, under a laparoscope, based on the diagnosis of endometriotic cyst. Histopathology revealed DIE with vaginal invasion. Immunostaining for CK7 was positive for endometriotic cyst, while CK20 was negative. The stromal cells in endometriosis were immunohistochemically positive for CD10. The vaginal fornix was well-healed one month later the surgery. Postoperatively, she got pregnant with her natural intercourse and delivered a healthy 2138 g girl at 36 weeks of gestation.
Highlights
Endometriosis is defined as the presence of endometrial glands and stroma abnormal located outside the uterine cavity
Our recently observed case of ovarian endometriotic cyst and Deep infiltrating endometriosis (DIE) with vaginal endometriosis that were diagnosed by vaginal cytology with immunocytochemistry of CK7 is reported
The vaginal cytology showing positive reactivity of CK7 in the glandular cells was useful for the diagnosis of the vaginal endometriosis
Summary
Endometriosis is defined as the presence of endometrial glands and stroma abnormal located outside the uterine cavity. It is a benign gynecological disorder affecting 6% - 10% of all women of reproductive age and presents an important cause of infertility [1]. Our recently observed case of ovarian endometriotic cyst and DIE with vaginal endometriosis that were diagnosed by vaginal cytology with immunocytochemistry of CK7 is reported. After the surgery, she got pregnant and was delivered a healthy girl after surgical treatment
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