Case presentation: T9-T11 transverse myelitis with double viral etiology in an immunocompetent host

Abstract

Case report We report the case of a 33-year-old woman who developed acute transverse myelitis with cerebrospinal fluid (CSF) findings suggestive for a central nervous system (CNS) infection with positive serology for acute herpes simplex virus-2 (HSV-2) infection and cytomegalovirus (CMV) DNA detection in CSF. This immunocompetent female patient presented with acute urine retention, complete absence of stool or gas and saddle paresthesia irradiated on the front of her lower limbs. Her spinal magnetic resonance imaging findings, CSF analysis and clinical picture were compatible with transverse myelitis. She also had skin rash resembling herpetic infection and her blood serology was positive for acute HSV-2 infection. She received treatment with IV acyclovir with partial resolution of the symptoms. Because of the persistence of symptoms for over 1 year and the presence of CMV IgG (previously negative) we performed further investigation that revealed positive PCR for CMV from the CSF. We initiated treatment with ganciclovir IV with good clinical response. After more than 1 year from the first symptoms, the patient is still under close supervision of the neurologist and the infectious diseases doctor, with almost total recovery, accusing only mild paresthesia and weakness in the lower limbs during effort.