Case of cutaneous nodular-plaque amyloidosis development

Abstract

Cutaneous amyloidosis is a rare disease that represents mesenchymal dysproteinosis and is characterized by amyloid deposition in the dermis. Generally, it has a benign course, but nodular-plaque option with progression can go into systemic form with unfavorable prognosis, therefore, a regular dynamic assessment of somatic status is necessary. A case of nodular-plaque amyloidosis of the skin is described. On the body of a 64-year old woman, on the outer surface of the lower extremities, symmetrically there were found multiple pinkish-cyanotic nodes 12 cm in diameter, having a dense consistency, which merged into irregularly-shaped tuberous plaques up to 6 cm in size with excoriated surface, covered with erosions and ulcerations, serohemorrhagic crusts, scaled desquamation. Foci of lichenification, depigmentation and cicatricial-atrophic changes in the skin were also determined. On the basis of clinical data and histological study, cutaneous nodular-plaque amyloidosis was diagnosed. Laboratory and instrumental research and consultations of related specialists (neurologist, therapist) allowed to exclude the systematic process.
 Describing this case, we would like to draw attention to a unique dermatosis, the only variant of cutaneous amyloidosis with potentially systemic lesion that requires special monitoring and control.