Abstract
Objective To investigate the changes of the serum sex steroids levels in prepuberal children with autism, and analyze the possible clinical implications. Methods The serum sex steroids, including follicle-stimulating hormone(FSH), luteotropic hormone(LH), testosterone(T), estradiol(E2), progesterone(P), dehydroepiandrosterone sulfate(DHEA-S) and androstenedione were measured in 44 autistic children(35 boys and 9 girls, 47.5±18.9 months) and 44 normal children(35 boys and 9 girls, 45.0±18.7 months), using chemiluminescence immunoassay. Results ①The progesterone levels in autism group were significantly lower than control group(( 0.05). ②The progesterone levels in 0.05). There were no statistical differences in progesterone level between the boys and girls of the autism group(Z=1.972, P>0.05). Conclusion The progesterone levels are lower in autistic children, and they are not associated with the children's age or gender. This study indicates that the progesterone levels are closely associated with autism. Key words: Autism; Sex steroids; Progesterone
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