Case-control study of expansion of heart cavity and great vessel diameters in acromegaly

Abstract

To investigate alternations of heart cavity and great vessel diameters and their risk factors in acromegalic patients. Ninety-two cases, diagnosed as acromegaly, were selected as research subjects from January 2013 to December 2013 in Peking Union Medical College Hospital. There were 37 males and 55 females with an average age of 41.2 years (SD, 12.5 years, range from 19 to 67 years old). Ninety-two sex and age matched healthy individuals were selected as controls. Disease history, echocardiography, endocrine hormone levels were collected to make contractive analysis. We analyzed the related risk factors of great vessel diameters expansion with binary logistic regression analysis and finally obtained the OR (odd ratio) and predictive formula. Left ventricle end-diastolic diameter (LVEDD), left ventricle end-systolic diameter (LVESD), left atrium longitudinal dimension (LALD), right ventricle longitudinal dimension (RVLD), aortic root dimension (AORD), ascending aorta (AA), main pulmonary artery (MPA) were higher in patients with acromegaly than in healthy people, P<0.05. The comparison between expanded vessel diameters and normal vessel diameters in acromegalics showed that difference of disease duration was of statistical significance, OR= 1.011. We got the formula: logit (ADE)=-3.420+0.011 × duration of disease. Heart cavity and vessel diameters in acromegalic patients were higher than that in public. Expanding of great vessel diameters mainly depend on duration of disease instead of serum GH and IGF-1 level, and the duration of disease is the risk factor of the expansion of great vessel diameters.