Abstract
AbstractThe novel 4‐aryl‐2‐aminopyridine compounds 3 have been synthesised via the regioselective cascade reaction of 1,1‐enediamines (EDAMs) 1 with (E)‐ethyl 2‐oxo‐4‐phenylbut‐3‐enoates 2 in EtOH promoted by piperidine. The reactions have the advantages of using an environmen tally friendly solvent and inexpensive starting compounds to produce good to moderate yield. This method provides a concise procedure for the highly regioselective synthesis of 4‐aryl‐2‐aminopyridine compounds.
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