Abstract
Poly(pentafluorophenyl methacrylate) (PPFPMA) was first subjected to post-polymerization modification with oligo(ethylene glycol) methyl ether amine (OEG-NH2) and yielded poly(pentafluorophenyl methacrylate)-co-poly(oligo(ethylene glycol methacrylamide)), PPFPMA-co-POEGMAM. These amphiphilic random copolymers can self-assemble into micellar nanoparticles in water having sizes less than 100nm. By tandemly reacting the pentafluorophenyl (PFP) groups in the copolymeric nanoparticles with a dithiol crosslinker, cystamine, redox-responsive nanogels can be formed. The last step of post functionalization with isopropylamine was introduced in order to remove the remaining PFP groups in the nanogels. Stepwise post functionalization can be monitored by FTIR and 19F NMR spectroscopy. Release of a model hydrophobic drug, nile red (NR) from the nanogels, simultaneously encapsulated during micelles formation, can be accelerated in the presence of glutathione (GSH) especially at 37°C. Results from cytocompatibility evaluation suggested that these developed redox-responsive nanogels strongly possessed a potential for applications in controlled delivery.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
