Abstract
AbstractMulticomponent reaction (MCR) has been one of the strong pillars of green chemistry. In this respect we herein report a multicomponent 5 step reaction in one pot by combining two known name reactions viz. Gould‐Jacobs reaction and Heck reaction for the synthesis of stilbene/biaryl‐quinolone hybrid molecules from readily available 4‐iodoaniline, (diethyl‐2‐(ethoxymethylene)malonate) EMME and styrene/aryl boronic acid. The use of diphenyl ether as a reaction solvent effectively mediated not only the Gould‐Jacobs reaction but surprisingly also the Heck reaction for the first time. Further, diphenyl ether also allowed easy isolation of crude product due to polar nature of the product via precipitation. The developed protocol thus offered unprecedented synthesis of hybrid molecules by converging five steps (Gould‐Jacobs reaction, Heck or Suzuki cross coupling, hydrolysis and decarboxylation) into one pot with simultaneous generation of C−C and C−N bonds besides cleavage of C−O and C−C bonds.
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