Abstract
Objective: It is well documented that long non-coding RNAs are vital in ovarian cancer (OC) occurrence and progression. The purpose of this study is to figure out the function of cancer susceptibility 19 (CASC19) in epithelial ovarian cancer (EOC), as well as its molecular mechanism. Methods: qRT-PCR was applied to determine CASC19 level in EOC tissues, serum and OC cells, and cell function tests to detect cell proliferation, migration and apoptosis. The impact of CASC19 on OC growth was determined by tumor allotransplantation. Results: CASC19 showed high expression in EOC tissues and serum, and OC cells. Patients with high expression had poor prognosis. CASC19 knockout could block OC cell malignant phenotypes in vitro, and its over-expression could reverse the above results. The tumor growth of nude mice was inhibited by CASC19 knockout. Conclusion: CASC19 is highly expressed in EOC patients. CASC19 knockdown can inhibit OC cell proliferation and invasion, and induce apoptosis, which is a promising therapeutic target for EOC.
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