Abstract
Molecular Biology Bacteria and their phages continually coevolve in a molecular arms race. For example, phages use anti-CRISPR proteins to inhibit the bacterial type I and II CRISPR systems (see the Perspective by Koonin and Makarova). Watters et al. and Marino et al. used bioinformatic and experimental approaches to identify inhibitors of type V CRISPR-Cas12a. Cas12a has been successfully engineered for gene editing and nucleic acid detection. Some of the anti-Cas12a proteins identified in these studies had broad-spectrum inhibitory effects on Cas12a orthologs and could block Cas12a-mediated genome editing in human cells. Science , this issue p. [236][1], p. [240][2]; see also p. [156][3] [1]: /lookup/doi/10.1126/science.aau5138 [2]: /lookup/volpage/362/240?iss=6411 [3]: /lookup/doi/10.1126/science.aav2440
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