Abstract
BackgroundThe cosmetic and pharmaceutical industries have an increasing interest in replacing synthetic antimicrobials in dermatological products due to increased microbial resistance to conventional antimicrobial agents. Pequi (Caryocar brasiliense) is a native fruit tree of the Brazilian Cerrado, specifically used in cosmetics, in the food industry, and for medicinal purposes. Leishmanicidal and antifungal activities have been reported previously. This study was designed to evaluate the antimicrobial and antioxidant activities of a C. brasiliense extract obtained by supercritical CO2 extraction.MethodsThe minimum inhibitory concentrations (MICs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were determined by the classical microdilution method. Antiseptic activity against these organisms was evaluated by the plate diffusion method. The antioxidant potential of the extract was evaluated using a method based on the oxidation of 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS). The extract’s chemical profile was analyzed for the presence of alkaloids, saponins, anthraquinones, steroids, tannins, flavonoids, and phenolic compounds according to standard colorimetric methods.ResultsThe C. brasiliense supercritical CO2 extract exhibits antimicrobial activity against all bacteria tested. It also possesses antioxidant activity, when compared to a vitamin E standard.ConclusionsThe C. brasiliense supercritical CO2 extract may be useful for the development of personal care products, primarily for antiseptic skin products that inactivate, reduce, prevent, or arrest the growth of microorganisms with the inherent intent to mitigate or prevent disease as well as products that minimize damage caused by free radicals.
Highlights
The cosmetic and pharmaceutical industries have an increasing interest in replacing synthetic antimicrobials in dermatological products due to increased microbial resistance to conventional antimicrobial agents
An apolar extract from C. brasiliense was prepared by Chemyunion Chemical Ltd., using a supercritical CO2 extraction system that consisted of a heated extraction column, CO2 and cosolvent pumps, a thermostatic bath, and a pressure gauge
The summarized values indicate the concentration of C. brasiliense supercritical extract (CBSE) that inhibited the growth of all microorganisms in the dilution tests. These results show that the inhibition values for E. coli and S. aureus growth are equivalent and are lower than those reported for P. aeruginosa
Summary
The cosmetic and pharmaceutical industries have an increasing interest in replacing synthetic antimicrobials in dermatological products due to increased microbial resistance to conventional antimicrobial agents. Methods: The minimum inhibitory concentrations (MICs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus were determined by the classical microdilution method Antiseptic activity against these organisms was evaluated by the plate diffusion method. Pequi oil is popularly employed for the treatment of hoarseness, sore throat, bronchitis, and cough or as a tonic It is topically used for dressing wounds, relieving muscle aches, rheumatic pains, and contusions [7]; lung infections and veterinary indications [8]; respiratory problems and scarring [9]; anti-inflammatory activity [10]; as an aphrodisiac, and for the stimulation of bile production [11]
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