Abstract
Background/aim:Natural products are popular insights for researchers to investigate promising anti-cancer agents since some of these substances have lesser adverse effects restricting the treatment than traditional chemotherapeutic agents. A well-known monoterpene Carvacrol, widely consumed in Mediterranean cuisine and lower risks of cancer, has efficient anticancer effects. However, the mechanism of action is yet to be discovered. Materials and methods The investigation aims to illuminate a new perceptive in the role of this substance on colorectal cancer treatment, by the means of differences in a well-defined range of soluble factors. Carvacrol effect on both HT-29 and HCT-116 cell lines was evaluated on proliferation and the IC50 values were calculated by the RTCA xCELLigence device. Then MAGPIX assay was performed to obtain the changes in soluble factors of the cell lines. Results The Multiplexing assay suggests some of these factors were altered in favor of surviving and proliferation in aggressive cell line HCT-116 whereas they were altered against these characters in HT-29, were correlated with the increased IC50 concentration of HCT-116 in carvacrol treatment. Conclusion The current study indicates that differences in the levels of these soluble factors could modulate the anticancer effect related to carvacrol.
Highlights
Colon cancer has become a major public health issue with 1,849,518 new cases in 2018. 10.2% of all cancer deaths in the same year were caused by this malign disease which brings it to the second rank in cancer related deaths [1]
The Multiplexing assay suggests some of these factors were altered in favor of surviving and proliferation in aggressive cell line HCT-116 whereas they were altered against these characters in HT-29, were correlated with the increased IC50 concentration of HCT116 in carvacrol treatment
The current study indicates that differences in the levels of these soluble factors could modulate the anticancer effect related to carvacrol
Summary
Colon cancer has become a major public health issue with 1,849,518 new cases in 2018. 10.2% of all cancer deaths in the same year were caused by this malign disease which brings it to the second rank in cancer related deaths [1]. The most accepted therapies are surgery, radiotherapy, and chemotherapy such as 5-fluorouracil and oxaliplatin [3,4]. All these procedures have their own difficulties, the adverse effects related to systemic chemotherapy are much restrictive due to their mortality. Since some of the natural products as chemotherapeutic agents indicate lower side effects on patients, they are promising anticancer agents and safer sources of cancer treatments.
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