Abstract
Cartilage, due to its unique physiology (lack of vasculature), can be potentially repaired using tissue engineered in the laboratory, by combining cells and with a supporting scaffold. This requires a marriage between material science, cell biology, and translational medicine, a concept well established as Tissue Engineering. Over the years the in vivo and in vitro chondrogenic potential of periosteum has been recognised by many researchers and as such periosteum is explored both to repair cartilage defects directly by transplanting periosteum into the cartilage defect or by using periosteum as a cell source for cartilage engineering purposes. The initial example hereof is the first generation of Autologous Chondrocyte Transplantation. Graft hypertrophy and ossification remain the primary drawbacks of cartilage repair strategies using engineered cartilage. These drawbacks may (partially) be due to the endochondral ossification process that can take over when cartilage is repaired. In this process chondrogenesis of progenitor cells is followed by hypertrophy of these cells and subsequent ossification. Periosteal progenitor cells go through this process in order to heal bone fractures. This review provides an overview of the role of periosteum in cartilage repair and cartilage tissue engineering and illustrates how periosteum can be used as a model to study the endochondral process. Such studies may provide clues to further optimize cartilage tissue engineering by identifying important factors which are capable of maintaining cells in their chondrogenic phenotype. Finally, the use of periosteum to engineer cartilage in vivo at an extra-articular site is described.
Highlights
The research area which combines cells with carrier materials to reproduce tissues in the laboratory is called Tissue Engineering (TE)
We have recently shown that cyclooxygenase-2 (COX-2) inhibitors are able to decrease chondrocyte hypertrophy
Periosteum was recognised for its chondrogenic capacity and as such has been explored as an autologous tissue for cartilage repair
Summary
The research area which combines cells with carrier materials to reproduce tissues in the laboratory is called Tissue Engineering (TE). The macromolecular arcade-like collagen architecture of cartilage, which is capable of withstanding an enormous amount of intensive and repetitive forces during life, is challenging to engineer. Both cartilage and bone are formed during a process called endochondral ossification. The difference in repair capacity may be partially explained by the presence or absence of periosteum and the lack of inherent vasculature in cartilage. The cambium layer of the periosteum, which is a source of mesenchymal progenitor cells, has been shown to be capable of forming cartilage and bone in vitro, ex vivo and in vivo [2]
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