Abstract
Purpose: Cartilage loss within the medial tibiofemoral (MTF) joint using MR images is widely used as a measure of OA structural progression. Automated segmentation provides results as accurate as manual methods and enables analysis of all OAI knees, including many healthy (non-OA) knees. The purpose of this study was therefore to determine the range of MTF cartilage thickness in healthy knees including the effect of covariates; the range of cartilage by KL grade (KLG); and the association of cartilage loss with the clinically important outcomes of pain, function and total knee replacement (TKR).
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