Abstract
Despite the fact that mesenchymal stem cells (MSC) offer clinical potential for osteoarthritis applications, retaining sufficient numbers of functional MSC at the site of injury for optimal repair still continues to be a major challenge. One method of overcoming this limitation is to create an artificial extracellular matrix or scaffold to hold the cells in place. Previous research suggests that biomaterials possessing an elastic modulus between 2-50MPa are suitable for functional cartilage repair. To this end, the main aim of this study was to examine the effect of scaffold mechanical properties on cartilage repair in a rabbit model in vivo.
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