Abstract
Purpose: Cartilage degeneration is one of the hallmarks in the development of osteoarthritis. LNA043 is a modified, recombinant version of the human angiopoietin-like 3 (ANGPTL3) protein acting directly on cartilage-resident cells to transmit a chondro-anabolic effect. A first-in-human study in patients scheduled for total knee replacement demonstrated a favourable safety profile and the modulation of several pathways involved in cartilage homeostasis and osteoarthritis (OA). A previous proof-of-mechanism study focussed on imaging using 7 Tesla magnetic resonance imaging (MRI) to show the formation of hyaline-like tissue after a single injection of 20 mg LNA04.
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