Abstract
Human gingival and rabbit polymorphonuclear leukocyte collagenases previously shown to be active against native monomeric skin and bone collagen, with the chain composition [α1(I)] 2α2, do not cleave native monomeric cartilage collagen, with the chain composition [α 1(II)] 3, as measured by a decrease in relative viscosity. Both types of collagen, however, are actively degraded by collagenase (EC 3.4.4.19) obtained from Clostridium histolyticum. The results strongly support the suggestion that collagen in cartilaginous structures is resorbed by a mechanism independent of that utilized in other tissues.
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