Abstract

ABSTRACTCartilage cell proliferation has been studied in the tail‐vertebrae of new‐born rats. At 1 day the median cycle time for cartilage cells was about 22 hr; G1+ 1/2M, S, and G2+ 1/2M being 6.8 ± 2.5, 11.6 ± 2.2, and 4.6 ± 2.0 hr respectively. At 7‐10 days, cell proliferation is confined mainly to the lower half of the epiphysis. Here cycle times are longer, about 3 1/2 days in the most active region. Differences in cycle times appear to be due to either a lengthening of G1 or the entry of cells into a resting state. Changes in cartilage cell kinetics are discussed in relation to the structure and function of the epiphysis.

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