Abstract
Cartilage-Bone Interface Features, Scaffold and Cell Options for Regeneration
Highlights
Tissues with different material and biological properties are connected to one another through interfaces, which can be generally categorized as soft-to-soft tissue interfaces, softto-hard tissue interfaces and hardto-hard tissue interfaces
Interface tissue engineering has recently attracted significant attention from academia to be able to understand the mechanism of cell-materials interactions relevant to interfaces
In order not to overload either tissue. This function is a direct consequence of hierarchical organization of the extracellular matrix (ECM) components forming the interface
Summary
Tissues with different material and biological properties are connected to one another through interfaces, which can be generally categorized as soft-to-soft tissue interfaces (muscle-tendon, etc.), softto-hard tissue interfaces (cartilage-bone, tendon-bone, etc.) and hardto-hard tissue interfaces (dentin-enamel, etc.). Since these interfaces merge biological materials, i.e., tissues, having distinct composition, structure and function, they possess complexities associated with their hierarchical structures, and when injured their healing/regeneration pathways follow more intricate phenomena compared to single tissues making up the interfaces. In order not to overload either tissue This function is a direct consequence of hierarchical organization of the extracellular matrix (ECM) components forming the interface. The major ECM components contained in these sub-tissues are collagen type II and glycosaminoglycans; collagen type I, glycosaminoglycans, minerals; and collagen type I and minerals, respectively (Table 1)
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