Abstract
Background Allergic rhinitis is characterized by Th2 polarization and defective IFN-γ production. Specific immunotherapy determines an allergen-specific clinical improvement. Aim of the study It was to evaluate whether a course of pre-seasonal SLIT with pollen allergen extract might affect the in vitro IFN-γ production using Dermatophagoides farinae (Df) allergen as stimulus, in patients presenting with rhinitis due to pollen allergy. Methods Thirty-nine AR patients with pollen allergy were included in the study. They assumed pre-seasonal SLIT for 3 months. IFN-γ-specific producing cells were assessed by cytokine ELISPOT before and 3 months after the SLIT course end. Results SLIT provided a significant increase of both pollen-induced and Df-induced IFN-gamma production ( p < 0.001). Conclusions The present study provides evidence that though the defective IFN-γ production is allergen-specific in allergic subjects, the SLIT increasing effects on IFN-γ may be non-specific.
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