Abstract
Tribal population constitutes 1.8 percent of total population of Bangladesh. The study was conducted in the tribal population of Bangladesh to detect haemoglobinopathies and beta thalassemia trait. Another purpose of the study was to create awareness about thalassaemia and haemoglobinopathies among these indigenous groups. It was a cross sectional study conducted from September 2015 to November 2015. A total of 460 random samples were collected from three tribal groups, 175 cases from Chakma, 187 cases from Garo and 98 cases from Marma. Two cc of venous blood were collected in EDTA tube. Haemoglobin variants were studied by HPLC method using Variant Hemoglobin Testing System (Variant II Beta Thalassemia Short Program). Statistical analysis was carried out using SPSS statistical package (version 15). Data was analyzed by frequency distribution. Abnormal Haemoglobin variants were seen in 287 cases (62.4%) out of 460 cases and only173 cases (37.6%) showed normal haemoglobin pattern. Haemoglobin E trait was the most common abnormality seen in 164 cases (35.6%) followed by Haemoglobin E disease which was seen in 101 cases (22%), Beta thalassaemia trait was seen in 22 cases (4.8%). This study shows a high percentage of Haemoglobin E trait and Haemoglobin E disease. Beta thalassaemia trait is also higher in comparison with randomly selected general population of Bangladesh. After calculating the estimate burden of child born per year by Harding Weinberg equation, it was to be found that the significant result which shows that 1552 new haemoglobin E beta thalassaemia and 22 new beta thalassaemia patients born per year in the tribal population. So, the tribal population should be properly screened and counseled for thalassaemia and haemoglobinopathies.
Highlights
Thalassemia and haemoglobinopathies are the most common congenital disorders in the world.[1]
Reliable data are still lacking from many regions of the world, recent data indicate that about 7% of the world populations are carrier of haemoglobin disorder and about 300,000500,000 children are born each year with the severe homozygous states of these diseases.[3]
This study showed that there was high frequency of haemoglobin E trait and haemoglobin E disease in the tribal groups, beta thalassaemia trait was little bit higher in comparison to the randomly selected general Bangladeshi population
Summary
Thalassemia and haemoglobinopathies are the most common congenital disorders in the world.[1]. In Bangladesh, there are about 45 different tribal groups spread across the country.[7] Chakmas are the largest ethnic group in Bangladesh They live in Rangamati, Khagrachhari and Bandarban of Greater Chittagong Hilltracts, they live in Teknaf of Coxsbazar. Majority of them live in Rangamati, Khagrachhari and Bandarban, some of them live in costal area of Teknaf and Patuakhali.[7] Marmas belong to the mongoloid races.[9] Garo population is another large indigenous communities in Bangladesh.[10] They live in the north-eastern part of Bangladesh, with the highest presence in the Gazipur, Mymensingh, Netrokona, Tangail, Sherpur, Jamalpur and Sylhet districts.[11] There is no accurate information about the ancestosr of Garos. Variant Hemoglobin Testing System (Variant II Beta Thalassemia Short Program, Bio-Rad Laboratories Inc., Hercules, CA, USA) under the experimental conditions specified by the manufacturer.[12]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
