Abstract
Syntheses of [ 18F]haloperidol and [ 18F]spiroperidol in both no-carrier-added and carrier-added forms have been accomplished. The no-carrier-added [ 18F]butyrophenone neuroleptics were prepared in low (<2%) yield by acid decomposition of aryl piperidine triazenes. Carrier-added 18F-neuroleptics were prepared in better (5–17%) yields by 18F-for- 19F nucleophilic aromatic substitution. The preparation of all synthetic precursors, and procedures for radiolabeling are fully described.
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