Abstract
Introduction: Since the early 20th century, findings have demonstrated that psoriasis is frequently associated with atherosclerosis and cardiovascular diseases. The Carotid Intima-Media Thickness (CIMT) is a surrogate marker of atherosclerotic vascular disease. Objective: The aim of this study was to investigate the CIMT in patients with psoriasis and investigate its correlation with the clinical features. Methods: The present case-control study involved 70 patients with psoriasis who visited Ho Chi Minh City Hospital of Dermato-Venereology from September 2018 to April 2019 and 35 healthy subjects. Serum triglyceride, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol levels were measured in both groups. Linear Doppler scanning was performed to evaluate the CIMT of the common, internal, and external carotid arteries and the presence of atherosclerotic plaques. Results: The mean CIMT value in psoriasis patients was significantly higher than that of controls [0.59 mm (0.53 - 0.71) vs. 0.54 mm (0.52 - 0.62), respectively, p = 0.036]. Multiple linear regression analysis revealed a significant correlation between the CIMT and age (p = 0.043) and CIMT and the Psoriasis Area and Severity Index (p < 0.0001). Moreover, the mean number of atherosclerotic plaques in psoriasis patients was significantly higher than that in controls [0.27 ± 0.68 vs. 0.03 ± 0.17, respectively, p = 0.035]. Conclusion: Elderly patients with severe psoriasis should be evaluated carefully regarding CIMT and atherosclerotic plaques, as these signs are representative of increased cardiovascular risk.
Highlights
Since the early 20th century, findings have demonstrated that psoriasis is frequently associated with atherosclerosis and cardiovascular diseases
Elderly patients with severe psoriasis should be evaluated carefully regarding Carotid Intima-Media Thickness (CIMT) and atherosclerotic plaques, as these signs are representative of increased cardiovascular risk
We found that the CIMT value in the psoriasis group was higher than that in controls (p < 0.05), and this difference was statistically significant
Summary
Since the early 20th century, findings have demonstrated that psoriasis is frequently associated with atherosclerosis and cardiovascular diseases. Psoriasis is a chronic inflammatory disease with the prevalence in the general population ranging from 0.51% to 11.43% in adults and 0% to 1.37% in children [1]. The progress of this disease is unpredictable, showing a persistent or recurrent course; no cure is currently available. Psoriasis is a systemic inflammatory disorder that may be associated with atherosclerosis and cardiovascular comorbidities [2]. This theory was supported by the “psoriatic march,” in which the systemic inflammation causes insulin resistance, resulting in endothelial cell dysfunctions. Atherosclerosis increases the risk of fatal complications, such as myocardial infarction, ischemic stroke, and arterial
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