Abstract
1. 1. Carotid body chemoreceptors were stimulated in normotensive and spontaneously hypertensive rats by intracarotid injection of nicotine or sodium dithionite. 2. 2. Stimulation of the chemoreceptors resulted in hyperventilation and a rise in blood pressure in both groups of rats. However the pressor response was much less in the hypertensive rats. 3. 3. When ventilation was controlled by artificial ventilation, carotid chemoreceptor stimulation resulted in a significant reduction in heart rate in both the normotensive and hypertensive rats. 4. 4. The observed responses were abolished by intracarotid injection of acetic acid suggesting that they are of carotid chemoreceptor origin.
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