Abstract
The peripheral chemoreflex is sensitised in both the spontaneously hypertensive rat (SHR) and Goldblatt renovascular hypertension (2K1C). We have previously shown CBD to chronically lower arterial pressure (AP) in SHR. Here, we test whether established 2K‐1C hypertension can be ameliorated by CBD. The left renal artery of 6 week old Wistar rats was partially occluded. At 11 weeks of age rats were instrumented to record AP telemetrically, and after a 7 day baseline recording underwent CBD (n=5) or Sham (n=2) surgery. Respiratory rate fell at Week 1 following CBD (75±1 vs. 61±2 breaths/min) but recovered by Week 3 (70±2 breaths/min). AP rose steadily during baseline (+0.9±0.6 mmHg/day CBD; +1.0±0.5 mmHg/day Sham); this continued in Sham (+1.3±1.0 mmHg/day) but not CBD (−0.3±0.9 mmHg/day). Thus, at week 1 AP was unchanged from baseline in CBD rats (183±16 vs. 182±17 mmHg), but increased in Sham (201±18 vs. 210±21mmHg). Spontaneous baroreflex gain increased in CBD (−1.16±0.16 vs. −1.25±0.15 bpm/mmHg) but not Sham (1.1±0.09 vs. 1.0±0.12 bpm/mmHg). Reductions in low (6.3±0.5 vs. 6.0±0.8 mmHg2) and very low frequency (2.8±0.5 vs. 1.8±0.2 mmHg2) spectral power of systolic AP were seen in CBD but not Sham, suggesting sympathoinhibition. In summary, CBD appears to halt the continued AP increase in 2K‐1C rat, possibly via improved baroreflex gain and/or sympathoinhibition. Cibiem & British Heart Foundation funded research.
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