Abstract
The purpose of this study was to define common carotid blood flow (CBF), cardiovascular and endocrine responses during head-up tilt (HUT) in patients with acute cerebrovascular diseases (CVD). In 31 male patients with acute CVD (damage of the supratentorial area) and 21 age-matched control male subjects, we measured CBF, mean blood pressure (MBP), heart rate, stroke volume and cardiac output responses before (baseline), during and after HUT. We also measured plasma levels of antidiuretic hormone, adrenaline, noradrenaline, aldosterone and plasma renin activity. After obtaining baseline measurements during 3-minutes horizontal position, HUT was performed for 5 minutes, followed by continuation of recording for 3 more minutes in the horizontal position. During HUT, CBF decreased significantly and equally in both groups. MBP did not change during HUT in both groups. The endocrine responses were also not different between the two groups. The results suggest that damage to the supratentorial area in patients with acute CVD do not alter the CBF, cardiovascular and endocrine responses. In other words, HUT does not predispose patients with acute CVD to serious falls in MBP and CBF at upright posture.
Highlights
Cardiovascular and endocrine responses to head-up tilt (HUT) and the regulation of these responses have been investigated thoroughly in healthy subjects (Vargas et al 1986; Laszlo et al 2001; Geelen et al 2002; Enishi et al 2004)
For mean blood pressure (MBP), the level remained stable during HUT in both groups, and there was no difference in MBP between the two groups throughout the entire test (Figure 1D)
The major findings of the present study were the following: 1) MBP did not change during HUT in both the patients and control subjects; 2) carotid blood flow (CBF) decreased during HUT in both groups instead of retention of MBP; and 3) the magnitude of decrease in CBF during HUT was similar in the patients and control subjects
Summary
Cardiovascular and endocrine responses to head-up tilt (HUT) and the regulation of these responses have been investigated thoroughly in healthy subjects (Vargas et al 1986; Laszlo et al 2001; Geelen et al 2002; Enishi et al 2004). The center that regulates the cardiovascular response during HUT is located in the medulla. It was reported that the blood pressure (BP) response to HUT in patients with chronic cerebrovascular diseases (CVD) is different from that of healthy people Rehabilitation programs often require patients to sit and stand, orthostatic training is important. Early rehabilitation, with emphasis on sitting and standing, for CVD patients is recommended for a better clinical outcome (Adams et al 2003; Bernhardt et al 2008). It is important to understand the symptoms, behavior of CBF, cardiovascular and endocrine responses during HUT in patients with acute CVD
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
