Abstract
The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer. This system ensures the drug release at the alkaline pH region where the drug has got maximum solubility. Further the study was concentrated on comparing the impact of gelling agent polyvinyl pyrrolidone on drug release. Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE). The optimized formulation of present study exhibited desired controlled drug release characteristics in the alkaline pH conditions and at acidic environment the drug dissolution was minimal as intended.
Highlights
Over the years, researches have paid greater attention on developing controlled release dosage forms, which invariably carries significant advantage over the conventional dosage forms
The study carried out here was focused on developing conventional monolithic controlled release matrix tablet of Atorvastatin calcium using carbomer as release controlling polymer
Quality by design tools were considered during formulation development and the polymer concentrations were optimized adopting the statistical tool, design of experiments (DoE)
Summary
Researches have paid greater attention on developing controlled release dosage forms, which invariably carries significant advantage over the conventional dosage forms. The goal in designing the controlled release delivery systems reduces the dosing frequency, ensuring consistent drug delivery and maintaining the therapeutic levels. Nair et al 190 better control of plasma drug concentrations and minimize the adverse effects with improved efficacy and constant delivery [1] [2] [3] [4]. Hydrogels have been widely used for the development of controlled release matrix tablets. The hydrogel in a swollen state maintains soft and rubbery state comparable to living tissues and displays excellent biocompatibility [5]. Carbopol resins exhibits ideal compressibilities and makes it suitable for direct compression process [6]
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