Abstract
ObjectiveThis study was to explore the inhibitory effects of carnosol on the growth and biofilm of Candida albicans. ResultsOur results showed that carnosol inhibited the planktonic growth of C. albicans with a MIC of 100 μg/mL. Carnosol can also inhibit the biofilm formation and development of C. albicans. 25–100 μg/mL of carnosol can obviously inhibit the yeast-to-hyphal transition in four kinds of hyphal-inducing media and the adhesion of C. albicans to polystyrene surfaces. Results from PI staining indicated that carnosol may disrupt cell membrane of C. albicans. ConclusionCarnosol can inhibit the planktonic growth and virulence factors of C. albicans, such as biofilm formation, adhesion and hyphal growth. The antifungal mechanism may involve the increase in cell membrane permeability.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
