Carnitine status before and after paracentesis in patients with ascites and liver cirrhosis and improvement of subjective symptoms by intravenous administration of carnitine ― Initial study

doi:10.28933/ojgh-2021-05-0506

Abstract

Highlights

Carnitine has been reported to be useful *Correspondence to Author: for improving blood ammonia and cognitive function in cirrhotic Naoki Hotta patients with subclinical hepatic encephalopathy In Japan, levo- Department of Internal medicine,Dicarnitine has become available, and there have been several vision of Hepatology,Masuko Mereports in which the carnitine concentration was first measured morial Hospital; 35-28 Takebashi and whether symptomatic patients improved or not
Total carnitine concentration was measured in 5 cir- How to cite this article: rhotic patients undergoing ascites drainage during our hospital Naoki Hotta.Carnitine status before ambulatory, and after ascites drainage, intravenous administra- and after paracentesis in patients tion of ercarnitine was conducted to examine whether or not the with ascites and liver cirrhosis and symptoms improved
Oral carnitine was administered in 3 patients (1 of carnitine ― Initial study .Open dialysis patient) because symptoms of cramps were noted, but in Journal of Gastroenterology and

Summary

Introduction

Method: Total carnitine concentration was measured in 5 cir- How to cite this article: rhotic patients undergoing ascites drainage during our hospital Naoki Hotta.Carnitine status before ambulatory, and after ascites drainage, intravenous administra- and after paracentesis in patients tion of ercarnitine was conducted to examine whether or not the with ascites and liver cirrhosis and symptoms improved. [4] Carnitine cramps during and at the end of golf, patients concentration and acylcarnitine/free carnitine were given branched-chain amino acid ratio were measured in this patient, and preparations and liver protection drugs as oral administration of ercarnitine preparation was medications. Three days carnitine was increased in all cases, and the later, the patient's cramps improved. Carnitine concentration 11 months after administration increased in all cases, and the ratio of Ascites drainage was performed once or twice a acylcarnitine/free carnitine was slightly week. The drainage increased the carnitine level without patient is currently hospitalized and discharged cramping or general malaise (Fig 2). The drainage increased the carnitine level without patient is currently hospitalized and discharged cramping or general malaise (Fig 2). from the hospital after drainage of ascites

Result

Conclusion

References: