Abstract
Abstract The oxygen polarograph was used to follow prostaglandin oxidation by rat liver mitochondria. This system exhibits an absolute requirement for exogenous carnitine and ATP, in contrast to the oxidation of prostanoyl carnitine which is stimulated by ADP in a very similar manner to palmityl carnitine. Prostaglandin E1, prostaglandin E2, prostaglandin F1α, prostaglandin F2α, prostaglandin A2, and 15-dehydroprostaglandin E2 exhibited ADP:O ratios in the range of 1.3 to 2.0, which is typical of normal fatty acids. Our data thus indicate that prostaglandins utilize the common carnitine-dependent system for the β oxidation of long chain fatty acids.
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