Abstract
Abstract The inotropic and anti-fatigue effects of d, l-carnitine, l-carnitine and d, l-acetyl-carnitine in laboratory animals were studied. In the isolated rabbit heart these substances at the concentration level of 10 −5 g/l increase significantly the contractile force depressed by anoxia, without changes in ECG, heart rate and coronary flow. The following rank order of activity was observed: d, l-acetyl-carnitine > l-carnitine > d, l-carnitine. Sodium acetate + d, l-carnitine mixture exerts the same inotropic effect as d, l-carnitine alone, showing the important role of the acetyl-bond. In rats submitted to a fatigue test (rotarod) only d, l-acetyl-carnitine induces a significant anti-fatigue effect. Since endogenous carnitine depletion is linked with many pathological states, particularly of the heart, exogenous carnitine and especially its acetyl-derivative might represent an important drug treatment with high tolerance advantages.
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